ADCYAP1 and migraine disorder: In addition, studies on new migraine-associated genes, visualization of early activated brain regions just before a migraine attack (e.g., hypothalamic and brainstem activation in collaboration with cortical spreading depolarisation), and the role for neuropeptides on pain (e.g., Pituitary adenylate cyclase-activating polypeptide, PACAP) (Rubio-Beltran et al., 2018) pave the path for new prophylactic options for migraine (Pascual, 2015; Charles, 2018; Harriott et al., 2019).