In addition, the methylation levels of ACTB_CpG_2.3 and ACTB_CpG_7.8 showed inverse correlation with current drinking status in controls (Spearman rho = -0.191 and -0.242, respectively, P < 0.020 for both, Supplementary Table 6), but not with drinking status in stroke cases (Supplementary Table 6). Here, ACTB is linked to stroke disorder.