BTK and influenza: TLSs in CBD were observed perivascular and peribronchial and in the parenchyma and are essentially comparable with TLSs seen in various other mouse models, including iBALT in influenza models and chronic house dust mite-driven allergic airway inflammation [60], as well as the perivascular TLSs seen in the spontaneous autoimmune model of B cell-specific overexpression of the signaling molecule Bruton's tyrosine kinase (Btk) [61].