SMO and pancreatic neoplasm: It has been reported that the clinical benefit of high-dose itraconazole in prostate cancer was mainly attributed to HH signaling inhibition rather than an anti-androgen effect.540 Moreover, vitamin D3 could also bind SMO with high affinity and is currently in phase I or phase III clinical trials as a neoadjuvant for the treatment of BCC, pancreatic cancer, CLL, and NHL.539