EED226 (MAK683) is a potent and selective PRC2 allosteric antagonist, which directly binds to the H3K27me3 pocket of EED and induces a conformational change, therefore disrupting EZH2-EED interaction and resulting in loss of PRC2 activity.428 EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. This evidence concerns the gene EED and lymphoma.