SOAT1 and rheumatoid arthritis: Distinct cytoplasmic domains of cytokine receptors activate different JAKs and STATs.312 The JAK/STAT pathway runs downstream of more than 50 cytokines and growth factors and is considered to be the central communication node for the immune system.JA-7 Given the important role of the JAK/STAT pathway in cytokine signal transduction, targeting JAK/STAT is considered a promising strategy for the treatment of multiple autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.