In a phase I trial for NSCLC patients who progressed after chemotherapy (NCT01068587), combined foretinib with erlotinib could achieve a response rate of 17.8% in the evaluated patients, and the clinical response was closely associated with baseline c-Met expression.58 In a phase I trial conducted in patients with advanced solid tumors (ISRCTN00759419), S49076 was administered orally once daily or twice daily in continuous 21-day cycles at escalating doses, followed by an expansion phase at the RP2D. This evidence concerns the gene MET and non-small cell lung carcinoma.