The phosphatidylinositol 3-kinase (PI3K)/V-AKT murine thymoma viral oncogene homolog (AKT)/mammalian target of rapamycin (mTOR) signaling pathway has an important role in cell growth, proliferation, survival, apoptosis, and motility and is frequently activated in human cancer.353 PI3Ks are a family of lipid kinases that catalyze the phosphorylation of phosphatidylinositol D3. The gene discussed is AKT1; the disease is cancer.