SOAT1 and hematopoietic and lymphoid cell neoplasm: Additionally, STAT signals (e.g., STAT3, STAT5, or STAT6) have been found to be frequently activated in malignant tumors, especially hematopoietic cancers and are involved in cell proliferation, survival, invasion, or inflammation.313 As the critical upstream protein of STAT signals, JAKs are also potential targets for cancer treatment.