Five TKIs of PDGFRs or KIT (imatinib, sunitinib, regorafenib, avapritinib, and ripretinib) are currently used clinically for GIST therapy.182 As target-specific inhibitors, avapritinib and ripretinib have shown extensive inhibitory effects on KIT or PDGFRα mutant GIST, and are potent for patients harboring primary or secondary resistant mutations, including the PDGFRα D842V mutant.183–185. This evidence concerns the gene KIT and gastrointestinal stromal tumor.