Specifically, breast invasive carcinoma (BRCA), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), and lung adenocarcinoma (LUAD) showed downregulation of ACSL4, while cholangial carcinom (CHOL), colon adenocarcinoma (COAD), and liver hepatocellular carcinoma (LIHC) had upregulated ACSL4 protein level (Fig. 1 and Fig. S1), which coincides with the previous findings that the specific role of ACSL4 in the tumor might vary according to the cancer type. The gene discussed is ACSL4; the disease is cancer.