EGFR and lung adenocarcinoma: Also, the effects of silencing or overexpression of ACSL4 on cell viability were relatively mild in some of the lung adenocarcinoma cell lines, suggesting that the expression level of ACSL4 may be only one of the factors that affect the tumor viability in lung adenocarcinoma and some other oncogenic pathways (e.g., EGFR pathway) may also play an important roles in tumor maintenance and progression.