INS and phenylketonuria: Previous studies have reported that Lachnospira abundance was negatively correlated with fasting blood glucose and the homeostasis model assessment of insulin resistances [19], while a decrease in Lachnospira was presented in individuals with increasing weights during pregnancy and premature delivery caused by preterm premature rupture of membranes, phenylketonuria, hand-foot-mouth disease, asthma, children with type 1 diabetes, and elders with Clostridioides difficile infection [16, 20–24], but significantly increasing in longevities [25].