Therefore, in this study, we used global Akt2‐KO mice with cardiomyocyte‐specifically overexpressing MT gene (MT‐TG/Akt2‐KO) to define whether these mice remain resistant to the development of DCM, that is whether the protection of MT against DCM exclusively depends on Akt2. Here, MCAT is linked to familial dilated cardiomyopathy.