In order to explore whether Akt activation could play a role in cardiac MT‐mediated DCM protection in Akt2‐KO mice, we examined the expression and phosphorylation levels of total Akt (t‐Akt) and of Akt1, the most prominent Akt isoform, as well as of Akt2 downstream proteins involved in regulating glucose metabolism. This evidence concerns the gene AKT2 and familial dilated cardiomyopathy.