At the molecular level, insulin resistance is characterized by an impaired insulin‐activated insulin receptor substrate/phosphoinositide 3‐kinase/Akt (IRS‐PI3K‐Akt) pathway, the major player in the metabolic action of insulin, which leads to suppressed insulin‐induced glucose uptake in insulin‐sensitive organs, including the heart.14, 15. The gene discussed is INS; the disease is Insulin resistance.