AKT1 and Insulin resistance: At the molecular level, insulin resistance is characterized by an impaired insulin‐activated insulin receptor substrate/phosphoinositide 3‐kinase/Akt (IRS‐PI3K‐Akt) pathway, the major player in the metabolic action of insulin, which leads to suppressed insulin‐induced glucose uptake in insulin‐sensitive organs, including the heart.14, 15