Previous studies have shown that metformin reduces long‐term and high insulin‐induced insulin resistance in cardiomyocytes,28 and AMPK has been shown to protect against insulin resistance in skeletal muscle cells through restoration of GLUT4 translocation29 Consistent with the findings of these previous studies, we found that metformin could improve HUA‐induced insulin resistance in primary cardiomyocytes. This evidence concerns the gene SLC2A4 and Insulin resistance.