Previous studies showed that adiponectin deficiency in middle‐aged mice leads to learning and memory impairments (Bloemer et al., 2019; Ng et al., 2016), while we revealed that Adiponectin level was correlated with both depressive behaviors and cognitive function in middle‐aged depression mice model induced by chronic stress, suggesting Adiponectin was a potential candidate responsible for both cognitive impairment and depression in elderly. The gene discussed is ADIPOQ; the disease is major depressive disorder.