Among them, TREM2 encodes an essential microglia sensor that mediates their response to environmental signals (Leyns et al., 2017), and its upregulation in microglia is closely related to inflammatory responses and pathogenesis of AD (Keren-Shaul et al., 2017; Ulland and Colonna, 2018). The gene discussed is TREM2; the disease is Alzheimer disease.