Recent studies have supported the central role of the SDF-1α/CXCR4 axis in regulating the mobilization of BM-EPC cells and its potential significance in cardiac repair through induction of angiogenesis and cardioprotective functions after myocardial infarction(Yin et al. 2017), as well as several intracellular signaling pathways(Wang and Luther 2012). Here, CXCR4 is linked to myocardial infarction.