In contrast, transgenic mice expressing both human mutant APOE form APOE*3-Leiden and human cholesteryl ester transfer protein (CETP) i.e. APOE*3-Leiden.CETP mice, feature a moderate and easy modifiable hyperlipoproteinemia and atherosclerosis phenotype[4, 5]. The gene discussed is CETP; the disease is hyperlipoproteinemia.