Palmitic acid also enhanced the production of acetyl-CoA, ATP, and ketone bodies, the metabolites of FAO, TCA cycle, and ketogenesis (Fig. S3, C–F) in vitro; A similar observation was also reported in a previous study in which fatty acids activate mitochondrial fatty acid oxidation to promote tumor growth in colon cancer21, whereby fatty acids activate the pathways of SOAT1-mediated fatty acid storage and CPT1A-mediated FAO. The gene discussed is CPT1A; the disease is neoplasm.