ETV4 and neoplasm: We then subcutaneously injected shETV4 cells into nude mice, ETV4 knockdown strongly retarded tumor growth and much smaller tumors were observed in mice inoculated with shETV4 cells compared with mice inoculated with control cells (Fig. 6D–F), which is consistent with previous reports52,53, and indicates that ETV4 is important for in vivo tumor growth.