PDK1 and breast cancer: Using transcriptome sequencing data of the CSC subpopulation in SUM149 human breast cancer cell line from GSE132083, we compared the glycolytic gene expression profiles between the CSC group and non-CSC group, and found that SLC2A1, HK2, ALDOA, ENO1, LDHA and PDK1 were upregulated in the CSC group (Fig. 3A).