Indeed, biofunctional analysis using IPA revealed that the main bio-function significantly affected by the expression of MDM4 was the “Protein synthesis” in both SK-OV-3 and ID8 cell lines (Fig. 4c and Fig. S4b), in agreement with a recent report model highlighting altered control of mRNA translational as a critical factor in cancer development and progression, also in OC42,43. This evidence concerns the gene MDM4 and cancer.