ICAM1 and psychiatric disorder: In addition, RT-qPCR analysis showed that the cytokine Tnf-α and the intercellular adhesion molecule-1 (Icam-1) were also elevated in the brain at this time (Supplemental Figure 4), both of which are highly relevant to brain inflammation in context of psychiatric disorders (Capuron and Miller, 2011, Müller, 2019).