This approach involves testing 5XFAD mice that overexpress mutant human APP with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) familial AD mutations along with human presenilin 1 (PS1) harboring two mutations, M146L and L286V (32), to resist acute HSV-1 infection. Here, PSEN1 is linked to Alzheimer disease.