While immune responses targeting myelin oligodendrocyte glycoprotein (MOG) have been extensively studied in experimental autoimmune encephalomyelitis [1], the clinical relevance of MOG-immunoglobulin (Ig)G was only recently appreciated following the identification of autoantibodies targeting conformational epitopes of full-length MOG in humans [2]. This evidence concerns the gene MOG and experimental autoimmune encephalomyelitis.