INS and myocardial infarction: Furthermore, a gain-of-function variant in TRB3 gene that has been identified and extensively characterized (i.e. Q84R, where arginine replaces glutamine at position 84; rs2295490) has been associated with in vitro [30, 31] and in vivo vascular insulin resistance [31] and earlier onset of myocardial infarction [27, 41].