CD8A and neoplasm: In BALB/c mice, DSPE-PEG-pheophorbide A liposome (DPPL) combined with laser irradiation of GEM-loaded DSPE-PEG-pheophorbide A liposome (GDPPL) stimulated a large number of CD4+ and CD8+ T cells to infiltrate HUCCT-1 tumor tissue due to exogenous stimulation of photomediated affiliates, while the PBS, DPPL and GDPPL treatment groups did not receive laser irradiation without any immune cells (Fig. 4c).