In BALB/c mice, DSPE-PEG-pheophorbide A liposome (DPPL) combined with laser irradiation of GEM-loaded DSPE-PEG-pheophorbide A liposome (GDPPL) stimulated a large number of CD4+ and CD8+ T cells to infiltrate HUCCT-1 tumor tissue due to exogenous stimulation of photomediated affiliates, while the PBS, DPPL and GDPPL treatment groups did not receive laser irradiation without any immune cells (Fig. 4c). The gene discussed is CD4; the disease is neoplasm.