One study found CD25 + FoxP3+ Tregs was positively associated with recurrence in vertical growth phase melanomas [16], whereas another study found CD25 + FoxP3+ Treg counts in tumor-stroma boundary were higher in atypical nevi and radial growth phase melanomas, compared with vertical growth phase melanomas and melanoma metastases [24]. The gene discussed is FOXP3; the disease is neoplasm.