KRAS and central nervous system cancer: For instance, the B-RAF proto-oncogene encoded protein has a regulatory role in the MAPK/ERK signaling pathway, which regulates glioma cell division and differentiation (Lassaletta 2017); KRAS mutations are associated with malignant progression of glioma (Fioravanzo 2019); the zinc finger E-box binding homeobox 1 can inhibit the transcription of interleukin-2 and inhibit the invasion and epithelial-mesenchymal transition of glioma cells (Siebzehnrubl 2013).