In addition, studies have shown that KIF14, a co-expressed gene positively associated with XRCC2, plays an oncogenic role in numerous cancers (Corson et al. 2005), FBXW4, a gene negatively associated with XRCC2, acts as a protective factor in metastatic colorectal cancer (Zhang 2020). This evidence concerns the gene XRCC2 and metastatic colorectal cancer.