JAK3 and neoplasm: Genes with copy gain or amplifications in multiple tumors included: CD300C which plays a role in innate immunity and antigen presentation via MHC class I and is a negative regulator of CD4 and CD8 T cells [31], JAK3, E2F4 and GLI1, which have canonical and non-cannonical roles in tumor cell proliferation respectively [32, 33], MDM2 which targets p53 for degradation [34], and MLL2 which may play a role in epithelial-mesenchymal transition (EMT) [35].