The KEGG pathways involved were mainly the neuroactive ligand-receptor interaction (hsa04080), cAMP signaling pathway (hsa04024), serotonergic synapse (hsa04726), dopaminergic synapse (hsa04728), glutamatergic synapse (hsa04724), PI3K-Akt signaling pathway (hsa04151), MAPK signaling pathway (hsa04010), long-term potentiation (hsa04720), calcium signaling pathway (hsa04020), Alzheimer disease (hsa05010) and soon. Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.