Depression related KEGG pathways were mainly involved neuroactive ligand-receptor interaction, cAMP signaling pathway, serotonergic synapse, dopaminergic synapse, glutamatergic synapse, PI3K-Akt signaling pathway, MAPK signaling pathway, long-term potentiation, calcium signaling pathway, Alzheimer disease and soon. This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.