We identified a total of 126 hallmark genes/proteins and 35 pairs of genes/proteins involved in PCa progression, in which 7 pairs of genes and 15 single genes are recommended as druggable targets to treat PCa, such as target pairs of Plk1 and DNMT3a (Tables S9 and S10, Supporting Information). This evidence concerns the gene PLK1 and posterior cortical atrophy.