Autophagy inhibition is now being explored in various clinical trials for patients with refractory malignancies including PCa.[28] Many autophagy inhibitors being investigated in PCa research including chloroquine, metformin in clinical trials.[29] In the present study, bioinformatics analysis revealed autophagy as a common death mode shared by Plk1 and DNMT3a (Figure 2H). This evidence concerns the gene DNMT3A and posterior cortical atrophy.