To investigate the developmental programmed and response to Plk1 and DNMT3a targets on the gene regulation level, a GRN inference method, Fast and Furious Bayesian Network (FFBN), is used to characterize the transcriptional causal regulation of Plk1 and DNMT3a in advanced PCa (Figure 2E). This evidence concerns the gene DNMT3A and posterior cortical atrophy.