The study of DNA methylation landscape of advanced PCa indicated the important regulatory role of DNA methylation of genes including TET and DNMT in metastatic PCa.[15] To further dissect how aberrations of gene methylation affect PCa progression, we downloaded 553 primary PCa patients’ data, including methylation microarray dataset and RNA sequencing profiles from TCGA, followed by analysis with R language. The gene discussed is DNMT1; the disease is posterior cortical atrophy.