Among them, we identified 18 genes of the tumor inflammation signature (TIS) (CCL5, CD27, CD276, CD274, CD8A, CMKLR1, CXCL9, CXCR6, HLA‐DQA1, HLA‐DRB1, HLA‐E, IDO1, LAG3, NKG7, PDCD1LG2, PSMB10, STAT1, and TIGIT) which has been previously associated with anti‐PD‐1/PD‐L1 response [28,29], 4 genes associated with CD8 T cells (CD8A, GZMM, CD8B, and PRF1), a marker of functional regulatory T cells (Treg) (FOXP3), a biomarker for B cells (CD19), and 4 macrophage‐related genes (C163, CD84, CD68, and CYBB) (Fig. 5). The gene discussed is PDCD1LG2; the disease is neoplasm.