ITGB3 and metastasis: Moreover, we have validated some previously reported overexpressed genes such as TGFB1, IBSP, MMP9, or ITGB3 in bone metastasis [4, 38, 39]; CRYAB, NRCAM, and SOX2 in brain metastasis [40, 41, 42]; VEGF and IL6 in lung metastasis [4, 43]; and CYP4F3 in liver metastasis [44].