ACOD1 and central nervous system cancer: In glioma pathogenesis, IRG1 was identified as a novel oncogene that promotes the growth and tumorigenesis of glioma (Pan et al., 2014); IRG1-mediated itaconate production potentiates peritoneal tumor growth, and IRG1 in peritoneal tissue-resident macrophages (pResMφ) represents a potential therapeutic target for peritoneal tumors (Weiss et al., 2018).