ACSS2 and hepatocellular carcinoma: ACSS2-knockout (KO) reduced the tumorigenesis of hepatocellular carcinoma in a mouse model, and ACSS2 expression was significantly elevated in hepatocellular tumors of mice and in a variety of human tumor samples, including breast, ovarian, and lung cancer tissues, as determined by immunohistochemical (IHC) staining (Comerford et al., 2014).