During pancreatic ductal adenocarcinoma (PDAC) progression, 6-phosphogluconate dehydrogenase (6PGD) -mediated oxidative pentose phosphate pathway (oxPPP) supports the reprogramming of histone H3K9 and DNA methylation, thereby promoting N-cadherin (epithelial-mesenchymal transition marker) transcription and N-cadherin-mediated distant metastasis (McDonald et al., 2017). This evidence concerns the gene CDH2 and pancreatic ductal adenocarcinoma.