IDH mutation-induced 2HG regulates DNA and histone methylation Two independent groups undertaking cancer genome sequencing projects identified IDH1 mutations in both glioblastoma multiforme and acute myeloid leukemia in 2008 and 2009, respectively (Parsons et al., 2008; Mardis et al., 2009). The gene discussed is IDH1; the disease is glioblastoma.