Thålin et al. found that a 3-fold increase in citrullinated histone H3 is associated with neutrophil activation markers neutrophil elastase (NE) and myeloperoxidase (MPO) and the inflammatory cytokines IL-6 and IL-8 in 60 patients with different advanced cancers (Thalin et al., 2018). Here, ELANE is linked to cancer.