Activated AKT (AKT serine/threonine kinase) phosphorylates ACLY, resulting in sustained histone acetylation under glucose deprivation conditions, and pAKT (Ser473) was positively correlated with histone acetylation levels in human glioma and prostate cancers (Lee et al., 2014). This evidence concerns the gene AKT1 and Familial prostate cancer.