In patient-derived acute myeloid leukemia (AML) cells, both the substrate and product of phosphoinositide 3-kinase (PI3K), phosphatidylinositol-(4,5)-bisphosphate (PIP2), and phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), respectively, bind to ACLY. Here, ACLY is linked to acute myeloid leukemia.