CASP10 and neoplasm: Under metabolic stress conditions, such as glucose starvation, increased caspase-10 downregulates intracellular lipid levels and represses GCN5-mediated histone H3 and H4 acetylation by ACLY cleavage, ultimately inhibiting the expression of tumor-related proliferative genes and metastatic genes as well as tumor progression (Kumari et al., 2019).