Pharmacological targeting of LSD1/CoREST/HDACs complex has showed very promising antitumor effect in human cancers.[31] Of note, in addition to modulate its histone substrates, LSD1 has been shown to repress tumor suppressors like p53 and FBXW7,[37] as well as to activate oncogenic signaling like androgen‐receptor‐dependent transcription[38] via distinct mechanisms. Here, RCOR1 is linked to cancer.