EGFR and cancer: OTUD7B has been reported to regulate cell cycle, tumorigenesis, neural progenitor cell differentiation, inflammatory responses, mucosal immunity, and diseases associated with the noncanonical NF‐kB pathway by catalyzing deubiquitination of substrates including Cyclin B, Aurora A, epidermal growth factor receptor (EGFR), GβL, Sox2, Zap70, and TRAF3.[12, 13, 14, 15] Genomic amplification of OTUD7B is frequently found across human cancers.