Given the increase in DNA damage and dysregulated expression of DNA damage sensors upon LDHC silencing, we speculated that, in analogy with treatment response of BRCA‐deficient tumor cells, LDHC silencing could improve the response to DNA damage response targeted therapy such as DNA damage inducers or DNA damage repair inhibitors that rely on DNA damage‐induced mitotic catastrophe to trigger cell death [62, 63]. Here, LDHC is linked to neoplasm.