We found that LDHC silencing increased the frequency and extent of polyploidy (≥ 4N) in MDA‐MB‐468 and BT‐549 cells (Fig. 2A,B) but not in breast cancer cells with inherent low levels of polyploidy (MDA‐MB‐231 and HCC‐1500). The gene discussed is LDHC; the disease is breast cancer.