Higher SDF‐1‐induced migration was observed in AML for CD34+ BM‐derived cells than in paired CD34+ peripheral blood (PB)‐derived cells, and a lower percentage of circulating leukaemia blasts in patients with a relatively high level of SDF‐1 induced migration indicated the role of CXCR4 in the anchoring of leukaemia cells in the BM.34 This evidence concerns the gene CXCL12 and acute myeloid leukemia.