Cocultivation of FLT3‐ITD mutated AML blasts or haematopoietic progenitor cells (HPCs) on BM stromal cells resulted in a strong proliferation advantage compared with FLT3‐wide‐type AML blasts, and addition of AMD3100 to the co‐culture significantly reduced the proliferation of FLT3‐ITD mutated cells, but did not affect FLT3‐wide‐type cells.59 This evidence concerns the gene FLT3 and acute myeloid leukemia.