In Han Chinese, a study showed that APOE-e4, the RS2305421 GG genotype, and the RS10498633 GT genotype are associated with the Aβ plaque score, Braak neurofibrillary tangle stage, and CERAD (Consortium to Establish a Registry for Alzheimer's disease) neuritic plaque score; these results have advanced our understanding of the pathogenesis of AD [21]. The gene discussed is APOE; the disease is Alzheimer disease.