HT reduces insulin secretion and increases insulin resistance in preclinical models and adult HT studies.60 Deranged postnatal glycemic control is an important risk factor for the adverse outcome as seen in the Coolcap study61 and is associated with specific patterns of brain injury in NE.62 Two piglets in the HT group had macroscopic abdominal organ necrosis, including the bowel, at post mortem. Here, INS is linked to Insulin resistance.