In this study, HGF treatment significantly promoted the proliferation of CRC cells and pcDNA3.1-Linc00284 plasmid (OE-Linc00284) transfection further enhanced the proliferation of CRC cells; however, si-Linc00284 transfection markedly reduced cell proliferative ability (Supplementary Fig. S9). This evidence concerns the gene HGF and colorectal carcinoma.