To understand the effect of Linc00284/miR-27a/c-Met axis on CRC cell proliferation and invasion, si-Linc00284, pcDNA3.1-Linc00284 plasmid (overexpression of Linc00284; OE 00284), pcDNA3.1-c-Met plasmid (overexpression of c-Met; OE c-Met), si-c-Met, miR-27a mimics or inhibitor was transfected into CRC cells as indicated in Fig. 7. The gene discussed is MET; the disease is colorectal carcinoma.