CDK4 and neoplasm: Notably, the expression levels of miR-27a, pro-apoptotic gene (Bax and Bid), tumor suppressor gene P53, epithelial markers (E-Cadherin and Cytokeratin19) were significantly upregulated, whereas the expression levels of oncogene c-Met, genes involved in cell cycle progression, including CDK4, CDK6 and CyclinD1, mesenchymal markers (N-Cadherin and Vimentin) and anti-apoptotic gene Bcl-2 were downregulated in tumor tissues (Linc00284 was silenced) compared to the control samples (Fig. 3F).