CDK4 and colorectal carcinoma: Data showed that overexpression of Linc00284 in CRC cells significantly upregulated the mRNA expression of genes involved in cell cycle progression, including CDK4, CDK6 and CyclinD1, mesenchymal markers (N-Cadherin and Vimentin) and anti-apoptotic gene Bcl-2), while the expression levels of pro-apoptotic gene Bax, epithelial markers (E-Cadherin and Cytokeratin19) were downregulated (Supplementary Fig. S5) compared to the control cells; however, transfection with miR-27a mimics partially reversed the expression levels of the above genes in CRC cells with Linc00284 overexpressing.