Our findings demonstrated that the silencing of Linc00284 significantly inhibited tumor growth in vivo without adverse effect on body weight of mice (Fig. 3A–C); meanwhile, the expression levels of cell proliferation markers Ki67 and Phosphohistone-H3 (pHH3) were markedly reduced in Linc00284 knockdown group in comparison to the control group (Fig. 3D, E). This evidence concerns the gene MKI67 and neoplasm.