CDCA3 and non-small cell lung carcinoma: As shown in Fig. 3b, endogenous CDCA3 levels were markedly reduced upon increased ectopic Cdh1 expression and less so with ectopic Cdc20 expression, suggesting that Cdh1, consistent with earlier reports8, is the predominant co-activator required to regulate levels of CDCA3 in NSCLC.