Out of twelve genetic variations, after applying the QC and HWE analysis, six variants TCF21 (rs12190287), ERCC1 (rs2298881, 11615), ERCC5 (rs751402), ARNTL (rs4757151), BRIP1 (rs4986764) showed strong significant association with non-small lung cancer in population of Jammu and Kashmir, North India with (OR = 1.46–2.12 and p value ≤ E10−3) while six variants REV1 (rs3792152), PIK3CA (rs2699887), CASC16 (rs3803662), DDC (rs2229080), ARNTL (rs1026071) and BCL2 (rs1801018) variants did not showed any significant association with NSCLC risk. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.