Our multiple Cox-proportional hazards model demonstrated that serum albumin concentration and hypoalbuminemia-related SNPs were deeply associated with an increased risk of hypertension development (albumin, HR = 0.654, 95% CI 0.521–0.820; rs2894536, HR = 1.176, 95% CI 1.015–1.361; rs10972486, HR = 1.152, 95% CI 1.009–1.316) after adjustment for age, sex, smoking history, SBP, DBP, body mass index, waist circumference, hemoglobin, platelet, hemoglobin A1c, alanine aminotransferase, γ-glutamyl transferase, TG, and HDL-cholesterol level (Table 4 and Supplementary Table S3). Here, ALB is linked to Hypoalbuminemia.