Given the large scale and rapid expansion of intratumoral Tc in irradiated Sirpα−/− mice, we postulated that the tumor antigen presentation by Sirpα−/− macrophages occurred in situ and led to a local anamnestic response via ‘calling’ tumor-specific memory T cells (i.e., TEM and TRM)39,40. Here, SIRPA is linked to neoplasm.