SIRPA and neoplasm: This anamnestic anti-tumor response, coupled with the activated Sirpα-deficient macrophage-mediated proinflammatory response, transforms the TME into a potent tumoricidal niche highly infiltrated by tumor-specific Tc, NK cells, and tissue-damaging neutrophils, while diminishing regulatory T cells (Tregs) myeloid-derived suppressor cells (MDSCs) and other immunosuppressive mechanisms.