SIRPA and neoplasm: Nanostring transcription profiling of the TME was also performed in Sirpα−/− and WT mice engrafted with Pan02 or KPC tumors, and similar results were observed revealing wide-ranging increases in the transcription of proinflammatory cytokines, immunogenic antigen presentation co-stimulatory molecules, T cell and neutrophil chemokines (CCL19/25/4 and CXCL1/3), as well as other essential molecules for anti-tumor immunity (Supplementary Fig. 5).