TGFB1 and neoplasm: Consequently, the drastic changes in the TME brought forth by activated Sirpα−/− macrophages culminated in rapid tumor elimination via large numbers of tumoricidal Tc and NK cells, infiltration of proinflammatory PMN, and a simultaneous reduction of immunosuppressive components including Treg, MDSC, and inhibitory cytokines such as TGFβ.