However, SIRPα deficiency combined with macrophage activation, herein achieved by DAMPs released by irradiated tumor cells, transformed intratumoral Sirpα−/− macrophages into exceptional antitumor effector cells that not only phagocytose tumor cells but also propagate the anti-tumor response by presenting tumor antigens to activate tumor-specific Tc. The gene discussed is SIRPA; the disease is neoplasm.