SIRPA and neoplasm: Notably, tumors infused with Sirpα−/− BMDMs in WT mice after IR also displayed similar robust expansion of GranzBhighp15E-reactive Tc, whereas those without infused Sirpα−/− BMDMs had poor induction of Tc (from 6 to 13%) that were mostly GranzBlow and lacked tumor-specificity (non-p15E reactive) (Fig. 4f).