For example, mutations in the human Wnt co-receptor LRP5 are associated with several high bone mass syndromes including osteopetrosis type I, and endosteal hyperostosis or autosomal dominant osteosclerosis, as well as a low bone mass disease, osteoporosis-pseudoglioma23–25. The gene discussed is LRP5; the disease is autosomal dominant osteosclerosis, Worth type.