In addition to these, HIT-MAP annotated the metabolic proteins cytochrome c oxidase subunit 6A1 and pyruvate kinase (Supplementary Fig. 4k, l); the Alzheimer’s disease-associated proteins neutrophilic granule protein and small EDRK rich factor 2 (Supplementary Fig. 4m, n); and the extracellular proteins a disintegrin and metalloproteinase domain-containing protein 22 (ADAM-22), hyaluronan and proteoglycan link protein 3, and wnt-2b (Supplementary Fig. 4o–q). Here, HAPLN3 is linked to early-onset autosomal dominant Alzheimer disease.