Similarly to previous studies using human CAR T cells targeting Her2, mesothelin, or CD1916,43,44, the production of IFNγ and TNF by anti-Lewis Y CAR T cells was significantly suppressed by NECA during coculture with Lewis Y+ OVCAR-3 tumor cells, an effect that was reversible through the addition of the A2AR antagonist SCH58261 (Fig. 7D). This evidence concerns the gene ADORA2A and neoplasm.