CRISPR/Cas9-mediated editing of A2AR rendered CAR T cells resistant to NECA in terms of their capacity to secrete IFNγ, TNF, and MIP1α (CCL3) upon coculture with either OVCAR-3 cells or MCF7 cells, another Lewis Y+ tumor cell line (Fig. 7E). This evidence concerns the gene CCL3 and neoplasm.