More broadly, A2AR knockdown enhanced the transcriptional expression of a wide range of effector-related genes following stimulation through the CAR (Fig. 2F) and increased the emergence of an activated TIM-3+Granzyme B+ subset upon serial coculture with Her2+ tumor cells to mimic differentiation within the tumor microenvironment (Fig. 2G). The gene discussed is ERBB2; the disease is neoplasm.