Protective pathways with increased gene expression levels included the genes for the defensins DefCR1 and DefA, whose altered production is suggested to be integrally involved in IBD pathogenesis29, and the genes for aldehyde dehydrogenases Aldh1A1 and Aldh1A2, whose expression is reduced in colonic macrophage and DC subsets of patients with ulcerative colitis regardless of inflammation30 (Fig. 5c). Here, ALDH1A1 is linked to ulcerative colitis.