Besides its antiangiogenic and antiproliferative effect, the pro-apoptotic effects of sorafenib have been reported to occur by different mechanisms, including downregulating of induced myeloid leukemia cell differentiation protein (MCL-1)7 and increasing the expression of the p53-upregulated modulator of apoptosis (PUMA, BBC3), which functions as a critical initiator of apoptosis in cancer cells8,9. Here, BBC3 is linked to cancer.