BCL2L1 and Thrombocytopenia: In summary, our data with AZD0466 indicates that novel nanomedicine delivery of BH3-mimetics can provide similar, if not increased efficacy in MPM, compared to currently available “unconjugated” BH3-mimetics, and can potentially overcome the major single-agent toxicity (i.e., thrombocytopenia) associated with BH3-mimetics targeting BCL-XL in general.