Recently, FGF23 has been linked to the development of anemia through its effects on erythropoietin production, erythroid cell apoptosis and cell cycle regulation.36 Similar to blood pressure modulation, these functions of FGF23 may appear to serve other purposes than maintaining phosphate homeostasis but hemodynamics could again help to explain how these effects favor the molecule’s phosphaturic effects. This evidence concerns the gene FGF23 and anemia.