Acute or prolonged stress is typically associated with insulin resistance to ensure sufficient glucose disposal to peripheral tissues.112–114 Along these lines, Ocn−/− mice exhibited reduced circulating levels of glucose after exposure to stress, suggestive of impaired counterregulatory mechanisms.74 However, previously published data has suggested that Ocn−/− mice are characterized by insulin resistance and obesity.111 As such, the lack of OCN apparently evokes opposing effects on glucose homeostasis under basal and stressful conditions, respectively. This evidence concerns the gene BGLAP and Obesity.