FGF23 and chronic kidney disease: Pertinent to this, FGF23 levels are associated with progression of CKD to end-stage renal disease, independent of traditional risk factors such as proteinuria.43 Moreover, glomerular hyperfiltration is a common mechanism in the pathogenesis of many kidney diseases including diabetic nephropathy44 and vice versa, pharmacological reduction of glomerular pressure (partly) protects against disease progression and reduces mortality.45–47