TMEM43 and heart disorder: Along with the variant spectrum of TMEM43 associated with the heart diseases reported in the human gene mutation database (Fig. 2 E, Top), the arginine at position 372 as well as amino acids in the transmembrane domain (TM) and loop regions of TMEM43 are highly conserved across organisms (Fig. 2 E, Bottom and SI Appendix, Fig. S3).