In this study, we compared the clinicopathologic characteristics and overall survival of Indonesian primary nodular melanoma cases with different mRNA levels of PD-L1 and NKG2A. Two important findings were observed: (1) cases with PD-L1 overexpression tended to have lower survival rates and (2) PD-L1 and NKG2A levels were strongly correlated. The gene discussed is CD274; the disease is nodular malignant melanoma.