Treatment of U87MG-CD4+CCR5+ cells (Fig. 7b) with G2-SN15-PEG FITC 1 μM or G3-SN31-PEG dendrimer caused a significant inhibition of HIV-1 infection, around 40%, in agreement with previously mentioned in the bibliography.34 Moreover, the treatment with some of the dendriplexes produced an increase of HIV-1 inhibition, for example hsa-miR-29A-3p with G2-SN15-PEG or G3-SN31-PEG dendrimer. This evidence concerns the gene CCR5 and HIV-1 infection.