The role of chromatin remodeling in pancreatic cancer has been heavily investigated as several genes involved in histone methylation (MLL2 and MLL3) and members of the tumor suppressing SWI/SNF complex (SMARCA1 and ARID1A) are recurrently mutated in PDAC tumors [35]. The gene discussed is SMARCA1; the disease is familial pancreatic carcinoma.