As one of the remarkable neurohormones from the heart, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is by far an effective indicator that have been verified for its role in predicting the outcomes in both ADHF and chronic heart failure (HF) [2–4], while its specificity and sensitivity remain low somehow [5, 6], which warrants a ADHF predictor with higher specificity and sensitivity. Here, NPPB is linked to hydrops fetalis.