TNFRSF1B and Autoimmunity: Although both TNFR1 and TNFR2 can trigger some common signaling pathways [20], TNFR2 activation generally promotes beneficial outcomes such as cell survival, induction of neurogenesis, and promotion of CNS autoimmunity [21, 22], while TNFR1 activity generally promotes detrimental outcomes such as cell death, aberrant neuronal plasticity, and exacerbation of the existing inflammatory response [21, 23, 24].