We observed that induction of acute pancreatitis increased the tendency for hippocampal CA1 astrocyte reactivity (increased GFAP expression) within 7 days, compared to non-pancreatitis mice (Fig. 5a, b, e), which was not apparent in the XPro1595-treated pancreatitis group (Fig. 5c–e). This evidence concerns the gene GFAP and acute pancreatitis.